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S7949951

ReagentPlus?,≥99% , 108-24-7

Synonym(s):
Acetic Anhydride;Acetyl acetate, Acetyl oxide;Acetyl Oxide,Ethanoic Anhydride, Acetic Acid

CAS NO.:108-24-7

Empirical Formula: C4 H6 O3

Molecular Weight: 102.09

MDL number: MFCD00008705

EINECS: 203-564-8

Update time: 2022-07-08

PRODUCT Properties

Melting point: -73.1 °C
Boiling point: 140 °C
Density  1.087
vapor density  3.5 (vs air)
vapor pressure  10 mm Hg ( 36 °C)
refractive index  n20/D 1.390(lit.)
Flash point: 130 °F
storage temp.  Store at RT.
solubility  Miscible with ether, chloroform and benzene.
form  Liquid
Specific Gravity 1.082
color  Colorless
Odor Very strong; pungent; vinegar-like characteristic odor.
PH 3 (10g/l, H2O, 20°C)
explosive limit 2.0-10.2%(V)
Odor Type acidic
Water Solubility  REACTS
Sensitive  Moisture Sensitive
Merck  14,56
BRN  385737
Exposure limits NIOSH REL: ceiling 5 ppm (20 mg/m3), IDLH 200 ppm; OSHA PEL: 5 ppm; ACGIH TLV: ceiling 5 ppm.
Dielectric constant 20.0
Stability: Stability Flammable. Incompatible with strong oxidizing agents, water, strong bases, alcohols.
LogP -0.58 at 20℃

Description and Uses

Acetic anhydride (chemical formula: (CH3CO)2O) is the simplest isolable anhydride of a carboxylic acid, is widely used as a reagent in organic synthesis. It has an internal asymmetric structure, leading to its potent electrophilicity. In organic chemistry, it is mainly used in acetylation for the manufacture of commercially significant materials, e.g. it can be used for the conversion of cellulose to cellulose acetate and aspirin. It can also be used as a wood preservative. In starch industry, it is a common acetylation compound for acetylation of monoglyceride. It is also an esterification agent for the production of modified starches. It is produced by carbonylation of methyl acetate or the reaction between ketene and acetic acid.

Acetic anhydride is an important solvent and acetylation agent. It is used for the manufacture of acetylcellulose, acetylsalicylic acid, acetanilide, nitrofurane, sulfonamides, vitamin B6 etc. As acetulizer and solvent in examining wool fat, glycerol, fatty and volatile oils, resins; detection of rosin. Widely used in organic syntheses, e.g., as dehydrating agent in nitrations, sulfonations and other reactions where removal of water is necessary.

Safety

Symbol(GHS) 
GHS02,GHS05,GHS06
Signal word  Danger
Hazard statements  H226-H302-H314-H330
Precautionary statements  P210-P280-P301+P312-P303+P361+P353-P304+P340+P310-P305+P351+P338
Hazard Codes  C,Xn,F,Xi
Risk Statements  11-20/21/22-37/38-41-34-20/21-10-20/22-19-40
Safety Statements  26-39-45-36/37/39-33-16
RIDADR  UN 2924 3/PG 2
OEL Ceiling: 5 ppm (20 mg/m3)
WGK Germany  3
RTECS  AK1925000
21
Autoignition Temperature 629 °F
TSCA  Yes
HazardClass  8
PackingGroup  II
HS Code  29152400
Toxicity LD50 orally in rats: 1.78 g/kg (Smyth)
IDLA 200 ppm

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