A7673312
Trifluoroacetic anhydride , 98% , 407-25-0
Synonym(s):
Bis(trifluoroacetic) anhydride, TFAA;TFAA;Trifluoroacetic anhydride
CAS NO.：407-25-0
Empirical Formula: C4F6O3
Molecular Weight: 210.03
MDL number: MFCD00000416
EINECS: 206-982-9
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | -65 °C (lit.) |
| Boiling point: | 39.5-40 °C (lit.) |
| Density | 1.511 g/mL at 20 °C (lit.) |
| vapor pressure | 6.28 psi ( 20 °C) |
| refractive index | n |
| Flash point: | -26 °C |
| storage temp. | 2-8°C |
| solubility | Miscible with benzene, dichloromethane, diethyl ether, dimethylformamide, terahydrofuran and acetonitrile. |
| form | Liquid |
| pka | 0.43[at 20 ℃] |
| Specific Gravity | 1.487 |
| color | Clear |
| Water Solubility | Hydrolysis |
| Sensitive | Moisture Sensitive |
| BRN | 746197 |
| Stability: | Stable, but moisture sensitive. Reacts with water to liberate hydrogen (flammable!). Incompatible with water, strong oxidizing agents. |
| LogP | 0.79 at 25℃ |
Description and Uses
Trifluoroacetic anhydride is used for the introduction of trifluoroacetyl group in organic synthesis. It is involved in the preparation of N- and O-trifluoroacetyl derivatives of a wide range of biologically active compounds for gas chromatography analysis. It plays an important role as desiccant for trifluoroacetic acid. It is also used in the oxidation of aldehydes to acids, esters, amides as well as in the protection of alcohols and amines. In addition, it is used as analytical reagents, solvents and dehydration condensing agent. It serves as an intermediate of fluorine fine chemicals, pharmaceuticals and agrochemicals.
Safety
| Symbol(GHS) |   GHS05,GHS07 |
| Signal word | Danger |
| Hazard statements | H314-H332-H412 |
| Precautionary statements | P273-P280-P301+P330+P331-P303+P361+P353-P304+P340+P312-P305+P351+P338+P310 |
| Hazard Codes | C,T |
| Risk Statements | 14-20-35-52/53-34-23/24/25 |
| Safety Statements | 26-36/37/39-43-45-61-9-8-28A-27 |
| RIDADR | UN 3265 8/PG 1 |
| WGK Germany | 2 |
| RTECS | AJ9800000 |
| F | 3-10 |
| Hazard Note | Corrosive/Moisture Sensitive |
| TSCA | T |
| HazardClass | 8 |
| PackingGroup | I |
| HS Code | 29159080 |
| Toxicity | skn-rbt 500 mg/24H SEV 28ZPAK -,91,72 |
