Poloxamer124 , EuropeanPharmacopoeia(EP)ReferenceStandard , 9003-11-6
Synonym(s):
3β,17α-Dihydroxy-5-pregnen-20-one;5-Pregnene-3β,17α-diol-20-one
CAS NO.：9003-11-6
Empirical Formula: C21H32O3
Molecular Weight: 332.48
MDL number: MFCD00021129
EINECS: 206-862-6
| Pack Size | Price | Stock | Quantity |
| P2163920 | RMB1158.11 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 273℃ |
| Flash point: | 9℃ |
| storage temp. | -20°C |
| solubility | Chloroform (Slightly), DMSO (Slightly, Heated, Sonicated) |
| form | Solid |
| Boiling point: | 478.4±45.0 °C(Predicted) |
| Density | 1.15±0.1 g/cm3(Predicted) |
| pka | 13.02±0.70(Predicted) |
| color | White to Off-White |
Description and Uses
17α-hydroxy Pregnenolone is a metabolite of pregnenolone and a precursor in the biosynthesis of dehydroepiandrosterone (DHEA; ). It is formed from pregnenolone by cytochrome P450 (CYP) isoform CYP17A1 hydroxylase activity and then converted to dehydroepiandrosterone by CYP17A1-mediated 17,20-lyase activity. Plasma levels of 17α-hydroxy pregnenolone are elevated in patients with type II 3β-hydroxysteroid dehydrogenase deficiency, a form of congenital adrenal hyperplasia.
17α-hydroxypregnenolone has been used as a substrate for the enzyme 3β‐hydroxysteroid dehydrogenase (3β‐HSD) expressed in COS1 cells.
Safety
| Symbol(GHS) |    GHS02,GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H225-H301+H311+H331-H370 |
| Precautionary statements | P210-P260-P280-P301+P310-P311 |
| Hazard Codes | F,T |
| Risk Statements | 11-23/24/25-39/23/24/25 |
| Safety Statements | 7-16-36/37-45 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol |
| WGK Germany | 3 |
| RTECS | TU5548000 |
