M9273134
A-966492 , 99% , 934162-61-5
| Pack Size | Price | Stock | Quantity |
| 1mg | RMB544.00 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Boiling point: | 605.5±65.0 °C(Predicted) |
| Density | 1.335 |
| storage temp. | Store at -20°C |
| solubility | ≥32.4 mg/mL in DMSO; ≥16.53 mg/mL in H2O with ultrasonic; ≥3.16 mg/mL in EtOH with gentle warming and ultrasonic |
| form | solid |
| pka | 9.33±0.30(Predicted) |
| color | White to off-white |
Description and Uses
A-966492 effectively inhibits PARP-1 with an EC50 of 1 nM and a Ki value of 1 nM. When it acts on PARP-2, the Ki value is 1.5 nM. It has excellent efficacy on PARP enzyme, especially on C41 cells. A-966492 significantly enhanced the effect of TMZ in a dose-dependent manner.
Safety
| Symbol(GHS) |   GHS07,GHS09 |
| Signal word | Warning |
