M9261834
AclacinomycinA , ≥98% , 57576-44-0
CAS NO.：57576-44-0
Empirical Formula: C42H53NO15
Molecular Weight: 811.88
MDL number: MFCD00866250
EINECS: 260-824-3
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB1440.00 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 151-153° (dec) |
| alpha | D24 -11.5° (c = 1 in methylene chloride) |
| Boiling point: | 756.05°C (rough estimate) |
| Density | 1.2261 (rough estimate) |
| refractive index | 1.6220 (estimate) |
| storage temp. | 2-8°C |
| solubility | Dichloromethane (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Yellow powder with orange cast. |
| pka | 6.41±0.70(Predicted) |
| color | Yellow powder |
| Stability: | Light Sensitive |
Description and Uses
Aclarubicin was found in the culture broth of Streptomyces galilaeus MA144-M1 by Umezawa et al. of the Institute of Microbial Chemistry in 1975. It was produced along with structurally related compounds showing antileukemic activity and named aclacinomycin A. Sanraku-Ocean cooperated in isolating aclacinomycin A as a yellow crystalline powder and evaluated its strong antileukemic activity and low cardiac toxicity. Its generic name was changed to aclarubicin on the recommendation of the World Health Organization.
Antineoplastic.
Safety
| Symbol(GHS) |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 36/37/39-45 |
| RIDADR | 3249 |
| RTECS | QI9279300 |
| HazardClass | 6.1(a) |
| PackingGroup | II |
| Toxicity | LD50 in mice (mg/kg): 22.6 i.p., 33.7 i.v. (Oki) |
