LeukotrieneC4(LTC4) , 250ug/mlinEthanol , 72025-60-6

Synonym(s):
6R-(((R)-2-((S)-4-amino-4-carboxybutanamido)-3-((carboxymethyl)amino)-3-oxopropyl)thio)-5S-hydroxyicosa-7E,9E,11Z,14Z-eicosatetraenoic acid;Leukotriene C₄ - CAS 72025-60-6 - Calbiochem;LTC₄, 5(S)-Hydroxy-6(R)-S-glutathionyl-7- trans-9- trans-11- cis-14- cis-eicosatetraenoic Acid

CAS NO.：72025-60-6

Empirical Formula: C30H47N3O9S

Molecular Weight: 625.77

MDL number: MFCD00151079

EINECS: 686-872-9

PRODUCT Properties

• Boiling point: 974.3±65.0 °C(Predicted)
• Density: 1.225±0.06 g/cm3(Predicted)
• Flash point: 11 °C
• storage temp.: −20°C
• solubility: 50mg/mL in DMSO, or in DMF
• form: Liquid
• pka: 2.21±0.10(Predicted)
• color: Colorless to light yellow

Description and Uses

Leukotriene C₄ (LTC₄) is the parent cysteinyl leukotriene produced by the LTC₄ synthase catalyzed conjugation of glutathione to LTA₄. LTC₄ is produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC₄-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute allergic hypersensitivity. The concentration of LTC₄ required to produce marked contractions of lung parenchymal strips and isolated tracheal rings is about 1 nM.

LTC4 (Leukotriene C4) is a potent agonist for contraction of smooth muscle, wtih many important immunomodulatory functions.

Safety

• Symbol(GHS): GHS02,GHS06,GHS08
• Signal word: Danger
• Hazard statements: H225-H301+H311+H331-H370
• Precautionary statements: P210-P233-P280-P301+P310-P303+P361+P353-P304+P340+P311
• Hazard Codes: F,T
• Risk Statements: 11-23/24/25-39/23/24/25
• Safety Statements: 36/37-45-16-7
• RIDADR: UN 1230 3/PG 2
• WGK Germany: 1
• RTECS: MB9143500