PRODUCT Properties
| Melting point: | 166-167°C |
| solubility | DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 0.5 mg/ml |
| form | A crystalline solid |
| color | White to off-white |
| LogP | 5.030 (est) |
Description and Uses
Evernic acid is a secondary metabolite produced by some species of lichen that can bind to allosteric sites on the protein surface of FAS-II enzymes and produce antibacterial and antiplasmodial effects. It inhibits two key plasmodial FAS-II enzymes PfFabZ and PfFabI (IC50 = 10.7 and 36.1 μM, respectively) but shows low efficacy against the malaria parasite P. berghei (IC50 = 77.3 μM).
