thielavin A , >95% by HPLC , 71950-66-8

CAS NO.：71950-66-8

Empirical Formula: C29H30O10

Molecular Weight: 538.54

MDL number: MFCD11111622

PRODUCT Properties

• Melting point: 235-236 °C
• Boiling point: 850.0±65.0 °C(Predicted)
• Density: 1.371±0.06 g/cm3(Predicted)
• storage temp.: Store at -20°C
• solubility: DMF: souble; DMSO: souble; Ethanol: soluble
• form: White to off-white powder.
• pka: 2.82±0.28(Predicted)

Description and Uses

Thielavin A is a fungal metabolite originally isolated from T. terricola that is related to thielavin B . Thielavin A inhibits COX, blocking both the conversion of arachidonic acid to prostaglandin H₂ (PGH₂; ) and the conversion of PGH₂ to PGE₂ (; IC₅₀s = 10 and 40 μM, respectively). Thielavin A also inhibits glucose-6-phosphatase in rat liver microsomes (IC₅₀ = 4.6 μM). It is a non-competitive inhibitor of α-glucosidase from S. cerevisiae (IC₅₀ = 23.8 μM; K_i = 27.8 μM).

Thielavin A acts as an inhibitor of prostagladins biosynthesis.