Tigogenin , Analysis of control products, 98% , 77-60-1
Synonym(s):
(25R)-5α-Spirostan-3β-ol
CAS NO.：77-60-1
Empirical Formula: C27H44O3
Molecular Weight: 416.64
MDL number: MFCD00067287
EINECS: 201-041-9
| Pack Size | Price | Stock | Quantity |
| 20mg | RMB480.00 | In Stock |
|
| 50mg | RMB980.80 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 202-204°C |
| alpha | -68 º (c=0.8g/100ml, CHCl3) |
| Boiling point: | 474.91°C (rough estimate) |
| Density | 1.0362 (rough estimate) |
| refractive index | 1.4700 (estimate) |
| storage temp. | -20°C Freezer, Under inert atmosphere |
| solubility | Chloroform (Slightly) |
| form | Solid |
| pka | 15.14±0.70(Predicted) |
| color | Off-White |
| optical activity | -67.218 (c 1, CHCl3) |
Description and Uses
Tigogenin is a steroidal sapogenin that has been found in A. sisalana and has diverse biological activities. It increases the proliferation rate of, as well as mRNA levels of genes encoding the osteoblastic differentiation markers Cbfa1, collagen type I, and osteocalcin in, mouse bone marrow stromal cells (BMSCs) in a concentration-dependent manner. It also increases matrix calcium deposition in BMSCs when used at concentrations of 30 and 90 μM. Tigogenin is active against the fungus A. fumigatus (MIC50 = 16 μg/ml). It inhibits carrageenan-induced paw edema in rats when administered at a dose of 4.2 μg/kg.
Tigogenin is a saponin structurally similar to Diosgenin (D484700) and acts as a natural plant steroid which induces apoptosis in rheumatoid arthritic fibroblast-like synoviocytes.
Safety
| RTECS | WH1443500 |
