PRODUCT Properties
| Melting point: | 211-216 ºC |
| alpha | D25 +17°; D25 +26.2° (ethylene chloride) |
| Boiling point: | 761.92°C (rough estimate) |
| Density | 1.1539 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| storage temp. | Store at -20°C, protect from light |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | Powder |
| pka | 5.4(at 25℃) |
| Stability: | Stable, but may be heat sensitive. Incompatible with strong oxidizing agents. |
Description and Uses
A complex dimeric alkaloid isolated from Vinca minor, this base has the structure given above based upon chemical and spectroscopic data. It resembles Vinblastine in its pharmacological action. Depending on the dosage, it causes either thrombocytosis with no effect upon the leucocytes, or thrombocytopenia accompanied by peucopenia in rats. Thrombocytosis persists even after prolonged treatment with drugs given in the correct dosage.
Antineoplastic[Note—Graphic formula same as for Vinblastine Sulfate, except that R is CHO].
Safety
| RIDADR | 1544 |
| HazardClass | 6.1(a) |
| PackingGroup | II |
| Toxicity | LD50 i.p. in mice: 5.2 mg/kg (Adamson) |
