Home Categories API MELPHALAN
A6034012

MELPHALAN , 90% , 148-82-3

Synonym(s):
L-PAM;L-Phenylalanine mustard;4-[Bis(2-chloroethyl)amino]-L-phenylalanine

CAS NO.:148-82-3

Empirical Formula: C13H18Cl2N2O2

Molecular Weight: 305.2

MDL number: MFCD00057717

EINECS: 205-726-3

Update time: 2022-07-08

PRODUCT Properties

Melting point: ~180 °C
Boiling point: 473.1±45.0 °C(Predicted)
alpha  D25 +7.5° (c = 1.33 in 1.0N HCl); D22 -31.5° (c = 0.67 in methanol)
Density  1.3587 (rough estimate)
refractive index  1.6070 (estimate)
storage temp.  -20°C Freezer
solubility  95% ethanol and 1 drop 6 N HCl: 0.05 g/mL, clear
form  powder
pka pKa 1.42/2.75/9.17(H2O,t =37.0,I=0.5) (Uncertain)
color  white
Water Solubility  <0.1 g/100 mL at 22 ºC
Merck  13,5850
BRN  2816456
InChIKey SGDBTWWWUNNDEQ-LBPRGKRZSA-N

Description and Uses

Melphalan is a nitrogen mustard derivative of the large neutral amino acid L-phenylalanine. It was first synthesized in 1953 by Bergel and Stock and is the active L-isomer of the compound. The D-isomer, known as medphalan, is less active against certain animal tumors, and the dose needed to produce effects on chromosomes is larger than that required with the L-isomer. The racemic (DL-) form is known as merphalan or sarcolysin.

antineoplastic, alkylating agent

Safety

Symbol(GHS) 
GHS06,GHS08
Signal word  Danger
Hazard statements  H300-H317-H340-H350-H361
Precautionary statements  P201-P280-P301+P310+P330-P302+P352
Hazard Codes  T+
Risk Statements  45-46-26/27/28-63-36/38-62
Safety Statements  53-22-36/37/39-45
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS  AY3675000
8
HazardClass  6.1(a)
PackingGroup  II
HS Code  29224999
Toxicity LD50 i.p. in rats: 14.7 mmol/kg (Ross)

RELATED PRODUCTS