MELPHALAN , 90% , 148-82-3

Synonym(s):
L-PAM;L-Phenylalanine mustard;4-[Bis(2-chloroethyl)amino]-L-phenylalanine

CAS NO.：148-82-3

Empirical Formula: C13H18Cl2N2O2

Molecular Weight: 305.2

MDL number: MFCD00057717

EINECS: 205-726-3

PRODUCT Properties

• Melting point: ~180 °C
• Boiling point: 473.1±45.0 °C(Predicted)
• alpha: D25 +7.5° (c = 1.33 in 1.0N HCl); D22 -31.5° (c = 0.67 in methanol)
• Density: 1.3587 (rough estimate)
• refractive index: 1.6070 (estimate)
• storage temp.: -20°C Freezer
• solubility: 95% ethanol and 1 drop 6 N HCl: 0.05 g/mL, clear
• form: powder
• pka: pKa 1.42/2.75/9.17(H2O,t =37.0,I=0.5) (Uncertain)
• color: white
• Water Solubility: <0.1 g/100 mL at 22 ºC
• Merck: 13,5850
• BRN: 2816456
• InChIKey: SGDBTWWWUNNDEQ-LBPRGKRZSA-N
• CAS DataBase Reference: 148-82-3(CAS DataBase Reference)
• IARC: 1 (Vol. 9, Sup 7, 100A) 2012
• EPA Substance Registry System: Melphalan (148-82-3)

Description and Uses

Melphalan is a nitrogen mustard derivative of the large neutral amino acid L-phenylalanine. It was first synthesized in 1953 by Bergel and Stock and is the active L-isomer of the compound. The D-isomer, known as medphalan, is less active against certain animal tumors, and the dose needed to produce effects on chromosomes is larger than that required with the L-isomer. The racemic (DL-) form is known as merphalan or sarcolysin.

antineoplastic, alkylating agent

Safety

• Symbol(GHS): GHS06,GHS08
• Signal word: Danger
• Hazard statements: H300-H317-H340-H350-H361
• Precautionary statements: P201-P280-P301+P310+P330-P302+P352
• Hazard Codes: T+
• Risk Statements: 45-46-26/27/28-63-36/38-62
• Safety Statements: 53-22-36/37/39-45
• RIDADR: UN 2811 6.1/PG 2
• WGK Germany: 3
• RTECS: AY3675000
• F: 8
• HazardClass: 6.1(a)
• PackingGroup: II
• HS Code: 29224999
• Hazardous Substances Data: 148-82-3(Hazardous Substances Data)
• Toxicity: LD50 i.p. in rats: 14.7 mmol/kg (Ross)