Vinpocetine , 99% , 42971-09-5

Synonym(s):
(3α,16α)-Eburnamenine-14-carboxylic acid ethyl ester;Eburnamenine-14-carboxylic acid ethyl ester

CAS NO.：42971-09-5

Empirical Formula: C22H26N2O2

Molecular Weight: 350.46

MDL number: MFCD00211233

EINECS: 256-028-0

PRODUCT Properties

• Melting point: 147-153 °C dec.
• alpha: D20 +114° (c = 1 in pyridine)
• Boiling point: 484.44°C (rough estimate)
• Density: 1.1260 (rough estimate)
• refractive index: 1.6500 (estimate)
• storage temp.: Sealed in dry,2-8°C
• solubility: DMSO: 5 mg/mL
• form: solid
• pka: 7.87±0.60(Predicted)
• color: white
• optical activity: [α]/D 148.5±5.0°, c = 0.1 in chloroform
• λmax: 315nm(EtOH)(lit.)
• Merck: 14,9991
• Stability: Photosensitive
• InChIKey: DDNCQMVWWZOMLN-IRLDBZIGSA-N
• LogP: 5.137 (est)
• NIST Chemistry Reference: Vinpocetine(42971-09-5)

Description and Uses

Vinpocetine (42971-09-5) is a phosphodiesterase PDE1 inhibitor (IC50=21 μM).1?Also blocks voltage-gated Na+?channels, IC50=44.2 μM (potency similar to phenytoin), a mechanism which may contribute to its neuroprotective and anticonvulsant activity.2?It reduces inflammatory IL-1β and TNF-α expression in rat hippocampus.3?Displays beneficial effects in a rat model of cerebral ischemia-reperfusion injury.4?Vinpocetine exerts neuroprotective effects by suppressing microglial inflammation.5

A calcium/calmodulin-dependent phosphodiesterase 1 (PDE1) inhibitor

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P264-P270-P301+P312-P501
• Hazard Codes: Xn
• Risk Statements: 22
• Safety Statements: 36
• WGK Germany: 3
• RTECS: JW4792000
• HS Code: 29399990
• Toxicity: LD50 in mice, rats (mg/kg): 534, 503 orally; 240, 133.8 i.p.; 58.7, 42.6 i.v. (Pálosi, Szporny), also reported as 161.2 mg/kg i.p. in mice (Cholnoky, Dmk)