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M5604535

Sancycline , ≥98% , 808-26-4

CAS NO.:808-26-4

Empirical Formula: C21H22N2O7

Molecular Weight: 414.41

MDL number: MFCD00864992

Pack Size Price Stock Quantity
5mg RMB785.60 In Stock
10mg RMB1339.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 224-2280C (dec)
Boiling point: 750.9±60.0 °C(Predicted)
Density  1.61±0.1 g/cm3(Predicted)
storage temp.  Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility  Aqueous Acid (Slightly), Chloroform (Slightly), Methanol (Slightly)
form  Solid
pka 4.50±1.00(Predicted)
color  Beige to Dark Beige
Stability: Hygroscopic
CAS DataBase Reference 808-26-4

Description and Uses

Sancycline is a semisynthetic tetracycline antibiotic that is more active than tetracycline against 339 strains of anaerobic bacteria (average MIC90s = 1 and 32 μg/ml, respectively). Sancycline is active against tetracycline-resistant E. coli, S. aureus, and E. faecalis strains with MICs ranging from 0.06 to 1 μg/ml. In vivo, sancycline is active against S. aureus in mice with ED50 values of 0.46 and 0.6 mg/kg for intravenous and subcutaneous administration, respectively.

Sancycline is a rare semi-synthetic tetracycline prepared by hydrogenolysis of the chloro and benzylic hydroxy moieties of declomycin, first reported in 1962. As the simplest of the early tetracyclines, sancycline was the first to be totally synthesised by Conover and co-workers. Like other tetracyclines, sancycline acts by reversibly binding to the 30S ribosomal subunit and inhibiting protein translation by blocking entry of aminoacyl-tRNA into the ribosome A site.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H362
Precautionary statements  P201-P260-P263-P264-P270-P308+P313

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