Salinomycin , ≥98% , 53003-10-4

Synonym(s):
Salinomycin

CAS NO.：53003-10-4

Empirical Formula: C42H70O11

Molecular Weight: 751

MDL number: MFCD25541652

EINECS: 258-290-1

PRODUCT Properties

• Melting point: 112.5-113.5 °C(lit.)
• alpha: D25 -63° (c = 1 in ethanol)
• Boiling point: 839.2±65.0 °C(Predicted)
• Density: 1.18±0.1 g/cm3(Predicted)
• Flash point: >110°(230°F)
• storage temp.: Sealed in dry,2-8°C
• solubility: insoluble in H2O; ≥142.2 mg/mL in EtOH; ≥91.8 mg/mL in DMSO
• form: White solid
• pka: 6.4 (DMF)
• color: White to light yellow
• optical activity: -6325 (cl, ethanol)
• Water Solubility: Soluble in methanol. Insoluble in water
• Merck: 13,8415
• Stability: Stable, but may be heat sensitive - keep cool. Incompatible with strong oxidizing agents.
• LogP: 5.596 (est)

Description and Uses

Salinomycin was found in the culture mycelium of Streptomyces albus by Otake et al. of the University of Tokyo in 1973. Like other polyether ionophore antibiotics, it shows activity against gram-positive bacteria, fungi, and Coccidium. Salinomycin has been used as a feed additive to protect poultry against coccidial infections.

Salinomycin was used as a standard in the development of LC-MS/MS method for detection of residual coccidiostats in egg and muscle samples. It was used to screen out CD44⁺CD24^- mesenchymal-like subpopulation within breast carcinomas.

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H300
• Precautionary statements: P264-P270-P301+P310-P405-P501
• Hazard Codes: T,Xi
• Risk Statements: 25-36/37/38
• Safety Statements: 45-36-26
• RIDADR: UN 3462 6.1/PG 2
• WGK Germany: 3
• RTECS: VO8620000
• F: 10
• HazardClass: 6.1(a)
• PackingGroup: II
• Toxicity: LD50 in mice (mg/kg): 18 i.p.; 50 orally (Miyazaki)