Cyclosporin A , 98% , 59865-13-3

Synonym(s):
Antibiotic S 7481F1;Cyclosporin A;Cyclosporin A, Tolypocladium inflatum - CAS 59865-13-3 - Calbiochem;Cyclosporine

CAS NO.：59865-13-3

Empirical Formula: C62H111N11O12

Molecular Weight: 1202.61

MDL number: MFCD00274558

EINECS: 611-907-1

PRODUCT Properties

• Melting point: 148-151°C
• Boiling point: 838.63°C (rough estimate)
• alpha: D20 -244° (c = 0.6 in chloroform); D20 -189° (c = 0.5 in methanol)
• Density: 0.9913 (rough estimate)
• refractive index: 1.6500 (estimate)
• Flash point: 87℃
• storage temp.: -20°C
• solubility: ethanol: 30 mg/mL
• form: solid
• pka: 13.32±0.70(Predicted)
• color: white
• optical activity: -18922 (methanol)
• Water Solubility: Soluble in dimethyl sulfoxide and ethanol. Insoluble in water.
• Merck: 14,2752
• BRN: 3647785
• Stability: Stable for 3 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
• InChIKey: PMATZTZNYRCHOR-CGLBZJNRSA-N
• CAS DataBase Reference: 59865-13-3(CAS DataBase Reference)
• IARC: 1 (Vol. 50, 100A) 2012
• EPA Substance Registry System: Cyclosporin A (59865-13-3)

Description and Uses

Cyclosporine A is a powerful immunosuppressive drug intended for preventing rejection of kidney, heart, and lung transplants. A new era in the development of immunopharmacology began with the discovery of cyclosporines. Cyclosporines are produced by mycelial mushrooms Tolypocladium inflatum, Tricoderma polysporum, and Cylindrocarpon lucidum, which are found in the ground.
Cyclosporine A is the first drug to affect a specific line of protecting cells of the body. Unlike usual cytotoxics, it suppresses T-cells and acts on all cell lines simultaneously. Cyclosporine A significantly eases the ‘reception’ of transplants, and increases the possibility of treating autoimmune system diseases.

An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. A group of nonpolar cyclic oligopeptides with immunosupppressant activity.

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Danger
• Hazard statements: H302-H350-H360FD
• Precautionary statements: P201-P202-P264-P270-P301+P312-P308+P313
• Hazard Codes: T,Xn,F
• Risk Statements: 45-60-22-40-36-20/21/22-11
• Safety Statements: 53-45-36/37-24/25-22-26-16
• RIDADR: UN 1648 3 / PGII
• WGK Germany: 3
• RTECS: GZ4120000
• HS Code: 29419090
• Hazardous Substances Data: 59865-13-3(Hazardous Substances Data)
• Toxicity: LD50 in mice, rats, rabbits (mg/kg): 107, 25, >10 i.v.; 2329, 1480, >1000 orally (Ryffel)