Minocycline hydrochloride , 98% , 13614-98-7

Synonym(s):
7-Dimethylamino-6-demethyl-6-deoxytetracycline, HCl;Minocycline hydrochloride;Minocycline, Hydrochloride - CAS 13614-98-7 - Calbiochem;Minomycin

CAS NO.：13614-98-7

Empirical Formula: C23H28ClN3O7

Molecular Weight: 493.94

MDL number: MFCD00083669

EINECS: 237-099-7

PRODUCT Properties

• Melting point: 205-210° (dec)
• Boiling point: 813℃
• Flash point: >110°(230°F)
• storage temp.: 2-8°C
• solubility: Sparingly soluble in water, slightly soluble in ethanol (96 per cent). It dissolves in solutions of alkali hydroxides and carbonates.
• form: crystalline
• color: yellow
• Water Solubility: Freely soluble in water
• Merck: 14,6202
• Stability: Light Sensitive
• InChIKey: GLMUAFMGXXHGLU-VQAITOIOSA-N
• SMILES: [C@@]12([H])C[C@@]3([H])C(C(=O)C4C(O)=CC=C(N(C)C)C=4C3)=C(O)[C@]1(O)C(=O)C(C(=O)N)=C(O)[C@H]2N(C)C.Cl |&1:0,3,21,31,r|
• LogP: 0.808 (est)
• CAS DataBase Reference: 13614-98-7(CAS DataBase Reference)

Description and Uses

Minocycline HCl (13614-98-7) displays antiapoptotic, anti-inflammatory1 activity. Prevents neuropathic pain in a rat sciatic nerve injury model.1 Reduces MMP-9 activity.2 Attenuates disease severity in mouse models of multiple sclerosis.3 Displays neuroprotective activity.4 Minocycline HCl may be effective in methotrexate-induced lung fibrosis.5?Orally active and brain penetrant.

antiinflammatory

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Danger
• Hazard statements: H317-H360-H362-H303-H315-H319-H335
• Precautionary statements: P201-P202-P260-P263-P264-P270-P272-P280-P302+P352+P333+P313+P363-P308+P313-P405-P501-P261-P280a-P304+P340-P305+P351+P338-P501a
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: 3249
• WGK Germany: 3
• RTECS: QI7630500
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 29413020
• Toxicity: human,TDLo,oral,14286ug/kg/10 (14.286mg/kg),LUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTIONLUNGS, THORAX, OR RESPIRATION: DYSPNEASKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE",Archives of Internal Medicine. Vol. 154, Pg. 1633, 1994.