PRODUCT Properties
| Melting point: | 129° |
| Boiling point: | 399.65°C (rough estimate) |
| Density | 1.2039 (rough estimate) |
| refractive index | 1.6110 (estimate) |
| storage temp. | Store at -20°C, protect from light |
| solubility | DMF: 2mg/mL; DMSO: 3mg/mL; DMSO:PBS (pH 7.2) (1:10): 0.09mg/mL; Ethanol: 1mg/mL |
| form | A solid |
| pka | 11.15±0.10(Predicted) |
| color | White to off-white |
Description and Uses
Chloroguanide is active with respect to exoerythrocyte and erythrocyte forms of plasmodia. It is most beneficial for suppressive therapy. It is used for preventing malaria, and it should be started 2 weeks before entering a malarial zone and should be taken for 8 weeks. Synonyms of this drug are biguanide, bigunal, paludrine, proguanil, and others.
Proguanil is medicaments; used in preparation of pyrrolecarboxamide derivatives as anti-malarial agents.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
