Orlistat , >97.0%(HPLC) , 96829-58-2

Synonym(s):
(−)-Tetrahydrolipstatin;N-Formyl-L-leucine (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester;Orlistat;Ro-18-0647

CAS NO.：96829-58-2

Empirical Formula: C29H53NO5

Molecular Weight: 495.73

MDL number: MFCD05662360

EINECS: 639-755-1

PRODUCT Properties

• Melting point: <50 °C
• alpha: D20 -32.0° (c = 1 in chloroform)
• Boiling point: 615.9±30.0 °C(Predicted)
• Density: 0.976±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMSO: 19 mg/mL
• form: solid
• pka: 14.59±0.23(Predicted)
• color: white
• Merck: 14,6869
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
• InChIKey: AHLBNYSZXLDEJQ-FWEHEUNISA-N
• SMILES: C(O[C@H](C[C@H]1[C@H](CCCCCC)C(=O)O1)CCCCCCCCCCC)(=O)[C@H](CC(C)C)NC=O

Description and Uses

Orlistat is a digestive lipase inhibitor. It inhibits diacylglycerol lipase α (DAGLα), DAGLβ, α/β-hydrolase domain-containing protein 12 (ABHD12), ABHD16A, and platelet-activating factor acetylhydrolase (PAF-AH; IC₅₀s = 0.06, 0.1, 0.08, 0.03, and 0.05 μM, respectively), as well as pancreatic lipase and hormone-sensitive lipase (IC₅₀s = 0.65 and 2.1 μg/ml, respectively) but does not inhibit fatty acid amide hydrolase (FAAH) or KIAA1363 (IC₅₀s = >100 μM for both). Orlistat decreases ionomycin-induced production of the endocannabinoid 2-arachidonoyl glycerol (2-AG) in N18TG2 murine neuroblastoma cells when used at a concentration of 1 μM. It also inhibits fatty acid synthase (FASN; K_iapp = ~0.1 μM for the human enzyme) and the proliferation of PC3 prostate cancer cells in a concentration-dependent manner. Orlistat (10 mg/kg) decreases serum cholesterol levels and total body weight in a mouse model of obesity induced by a high-fat diet. Formulations containing orlistat have been used in the treatment of adult obesity.

Orlistat is an antiobesity agent. Orlistat is an pancreatic lipase inhibitor.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H412
• Precautionary statements: P273
• WGK Germany: 3
• RTECS: OH3167600
• HS Code: 29322090