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A2976612

Chloroquine , 97% , 54-05-7

CAS NO.:54-05-7

Empirical Formula: C18H26ClN3

Molecular Weight: 319.87

MDL number: MFCD00024009

EINECS: 200-191-2

Pack Size Price Stock Quantity
50MG RMB23.20 In Stock
250MG RMB48.00 In Stock
1G RMB153.60 In Stock
5G RMB719.20 In Stock
25g RMB2709.60 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 87°
Boiling point: 475.41°C (rough estimate)
Density  1.0500 (rough estimate)
refractive index  1.6010 (estimate)
storage temp.  2-8°C(protect from light)
solubility  Chloroform (Slightly), Methanol (Slightly)
form  Solid
pka pKa 8.4(H2O t = 20) (Uncertain)
color  White to Light Brown
Stability: Stable, but light sensitive. Incompatible with strong oxidizing agents.
IARC 3 (Vol. 13, Sup 7) 1987
EPA Substance Registry System 1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl- (54-05-7)

Description and Uses

Chloroquine is the most effective of the hundreds of 4-aminoquinolines synthesized and tested during World War II as potential antimalarials. Structure–activity relationships demonstrated that the chloro at the 8-position increased activity, whereas alkylation at C-3 and C-8 diminished activity. The replacement of one of its N-ethyl groups with an hydroxyethyl produced hydroxychloroquine, a compound with reduced toxicity that is rarely used today except in cases of rheumatoid arthritis.

Chloroquine used in the treatment of malaria and MDR-strains. It is a COVID19-related research product.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
Hazardous Substances Data 54-05-7(Hazardous Substances Data)
Toxicity LD50 oral in rat: 330mg/kg

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