Hydroxychloroquine sulfate , ≥98% , 747-36-4

Synonym(s):
7-Chloro-4-[4-(N-ethyl-N-b-hydroxyethylamino)-1-methylbutylamino]quinoline sulfate;Hydroxychloroquine sulfate

CAS NO.：747-36-4

Empirical Formula: C18H28ClN3O5S

Molecular Weight: 433.95

MDL number: MFCD00078203

EINECS: 212-019-3

PRODUCT Properties

• Melting point: 240 °C
• storage temp.: protect from light
• solubility: H2O: >20mg/mL
• form: Crystalline Powder
• color: white to off-white
• Water Solubility: FREELY SOLUBLE
• Merck: 14,4818
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 3 months.
• InChIKey: JCBIVZZPXRZKTI-UHFFFAOYSA-N
• EPA Substance Registry System: Ethanol, 2-[[4-[(7-chloro-4-quinolinyl)amino]pentyl]ethylamino]-, sulfate (1:1) (747-36-4)

Description and Uses

Hydroxychloroquine is an aminoquinoline with antimalarial, anti-inflammatory, and antiviral activities. It is active against the chloroquine-sensitive NF54 and D6 strains of P. falciparum (IC₅₀s = 16.3 and 15 nM, respectively) but has decreased activity against chloroquine-resistant P. falciparum strains (IC₅₀s = 422.7-1,735.3 nM). Hydroxychloroquine inhibits production of IL-22, IL-17A, and IL-6 induced by phorbol 12-myristate 13-acetate (TPA; ) and ionomycin in peripheral blood mononuclear cells (PBMCs) isolated from healthy individuals or patients with systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA). It inhibits accumulation of sequestosome-1 (SQSTM1) puncta, a marker of autophagy, in mouse embryonic fibroblasts (MEFs) in a concentration-dependent manner. Hydroxychloroquine reduces viral titers of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the culture supernatant of infected Vero E6 cells but does not reduce SARS-CoV-2 viral titers in an in vitro human airway epithelium model or the respiratory tract of infected cynomolgus macaques. Formulations containing hydroxychloroquine have been used in the prevention or treatment of malaria, as well as in the treatment of RA and SLE.

antimalarial, lupus suppressant

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319
• Precautionary statements: P301+P312+P330-P305+P351+P338
• Hazard Codes: Xn,Xi
• Risk Statements: 42/43-36/37/38-36-22
• Safety Statements: 37/39-26
• WGK Germany: 3
• RTECS: KK3342500
• HS Code: 29334990