Lasalocid , 98% , 25999-31-9

CAS NO.：25999-31-9

Empirical Formula: C34H54O8

Molecular Weight: 590.79

MDL number:

EINECS: 247-401-9

PRODUCT Properties

• Melting point: 110-114°; mp 100-109° (unsharp)
• alpha: D25 -7.55° (methanol)
• Boiling point: 735.7±60.0 °C(Predicted)
• Density: 1.119±0.06 g/cm3(Predicted)
• storage temp.: -20°C Freezer, Under inert atmosphere
• solubility: Acetonitrile,(Slightly), Methanol (Slightly, Sonicated)
• form: Solid
• pka: 3.15±0.39(Predicted)
• color: White to Off-White

Description and Uses

Lasalocid is an ionophore antibiotic isolated from certain Streptomyces sp. and used in veterinary practice as a coccidiostat for gastrointestinal parasites. Lasalocid cytotoxicity targets cell metabolism, demonstrating EC₅₀ values in the range of 7-20 μM in viability assays using chicken hepatoma LMH cells and rat myoblast L6 cells.

Lasalocid is an anticancer supplement agent comprising of polyether antibiotic for treating brain tumors, also inhibits mitochondrial GPD2 activity and elicits anti-proliferative effects on cancer cells.

Safety

• Toxicity: LD50 in mice (mg/kg): 40 i.p. (Berger); also reported as LD50 in mice (mg/kg): 146 orally, 64 i.p., J. W. Westley, "Antibiotics (Polyether)" in Kirk-Othmer Encyclopedia of Chemical Technology Vol. 3 (Interscience, New York, 3rd ed., 1978) p 61