Anacardicacid , 10mMinDMSO , 16611-84-0

Synonym(s):
22:0-Anacardic acid;2-Hydroxy-6-pentadecylbenzoic acid;6-Pentadecylsalicylic acid;Anacardic acid

CAS NO.：16611-84-0

Empirical Formula: C22H36O3

Molecular Weight: 348.52

MDL number: MFCD07368254

PRODUCT Properties

• Melting point: 90-91℃
• Boiling point: 474.8±33.0 °C(Predicted)
• Density: 1.002
• storage temp.: -20°C
• solubility: DMSO: ≥20mg/mL
• form: White solid
• pka: 3.08±0.30(Predicted)
• color: white to beige
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
• InChIKey: ADFWQBGTDJIESE-UHFFFAOYSA-N
• LogP: 9.960 (est)

Description and Uses

Anacardic acid, isolated from cashew shells or several other medicinal plants, is the general name given to a family of four different 6-alkyl salicyclic acids having varying degrees of unsaturation in the 15-carbon alkyl chain. These compounds are associated with anti-inflammatory, anti-tumor, molluscicidal, and anti-microbial activity. Literature frequently sites and gives the name anacardic acid to the completely-saturated compound (6-pentadecyl salicylic acid). Anacardic acid inhibits the histone acetyltransferase (HAT) activity of the transcription co-activators p300 and p300/CREB-binding protein-associated factor (PCAF) with IC₅₀ values of 8.5 and 5 μM, respectively. At 25 μmol/L, anacardic acid suppresses NF-κB activation, inhibits IκB-α phosphorylation, and prohibits p65 nuclear translocation in KBM-5 cells.

2-Hydroxy-6-pentadecyl Benzoic Acid, is a compound that is used to treat agriculture from various fruit insects. Derivative of this molecule has been also shown to be a potent activator of human 5-lipoxygenases (5-LOX).

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319
• Precautionary statements: P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
• Hazard Codes: Xi
• Risk Statements: 36
• Safety Statements: 26
• WGK Germany: 3