PRODUCT Properties
| Melting point: | 190°C |
| Boiling point: | 250 °C(Press: 0.1 Torr) |
| Density | 1.1020 (rough estimate) |
| refractive index | 1.5400 (estimate) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), DMSO (Sparingly), Ethanol (Slightly), Methanol (Slightly, |
| form | Oil to Gel |
| pka | pKa 1.96± 0.05；7.40± 0.03(H2O,t =24.5±0.5)(Approximate) |
| color | Colourless to Yellow |
| Water Solubility | < 700 mg/mL |
| BCS Class | 2 |
Description and Uses
Hydroxyzine is an antihistamine drug with M-cholinoblocking properties and expressed action on the CNS. It suppresses subcortical regions of the CNS including the limbic system and reticular formation. It potentiates the effect of narcotic analgesics and exhibits sedative effects.
It is used as a sympthomatic drug for atopic dermatitis as a sedative drug before and after operational interventions, for preventing vomiting and diarrhea, and for relieving agitation and emotional disorders. Synonyms of this drug are atarax, durrax, and vistaril.
Safety
| Symbol(GHS) |   GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H334-H372-H360-H336-H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P261-P285-P304+P341-P342+P311-P501-P260-P264-P270-P314-P501-P261-P271-P304+P340-P312-P403+P233-P405-P501 |
| Toxicity | LD50 oral in rat: 840mg/kg |
