Exemestane , 98% , 107868-30-4

Synonym(s):
6-Methyleneandrosta-1,4-diene-3,17-dione;Exemestane

CAS NO.：107868-30-4

Empirical Formula: C20H24O2

Molecular Weight: 296.4

MDL number: MFCD00866994

EINECS: 643-090-2

PRODUCT Properties

• Melting point: 155.13°C
• Boiling point: 453.7±45.0 °C(Predicted)
• Density: 1.13±0.1 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMSO: ≥20mg/mL
• form: powder
• color: white to off-white
• optical activity: [α]/D +250 to +300°, c = 1 in methanol
• InChI: InChI=1S/C20H24O2/c1-12-10-14-15-4-5-18(22)20(15,3)9-7-16(14)19(2)8-6-13(21)11-17(12)19/h6,8,11,14-16H,1,4-5,7,9-10H2,2-3H3/t14-,15-,16-,19+,20-/m0/s1
• InChIKey: BFYIZQONLCFLEV-DAELLWKTSA-N
• SMILES: C1(=O)C=C2[C@](C)(C=C1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)C(=O)CC3)CC2=C

Description and Uses

Exemestane was launched in US and other countries for the treatment of estrogendependent tumors and postmenopausal breast cancer. It is a novel steroidal compound structurally related to the natural substrate for the biosynthesis of estrogen, androstanedione, and can be synthesized by methylidenation of androsta-1, 4-dien- 17beta-ol-3-one in 6 position then oxidation of the alcohol function. Exemestane is an irreversible inactivator of the aromatase enzyme system, so inducing in vivo a dose-related sustained suppression of serum estrogen and minimal endocrine activity. It is the first steroidal representative of the third-generation of orally active aromatase inhibitors with a highly potent and selective mechanism of action, displaying good tolerability and safety profile. In rats with DMBA-induced mammary tumors, 10 to 100 mglkg of exemestan administered po twice-daily for 4 weeks resulted in 76 to 88% regression. In women failing anti-estrogen therapy with tamoxifen, this agent has demonstrated high activity in locally advanced or metastatic disease. In addition, it may also have potential for breast cancer prevention.

antiinfective

Safety

• Symbol(GHS): GHS08,GHS09
• Signal word: Danger
• Hazard statements: H360-H411
• Precautionary statements: P201-P202-P273-P280-P308+P313-P391
• Hazard Codes: T,N
• Risk Statements: 60-61-51
• Safety Statements: 53-22-36/37-57
• WGK Germany: 3
• HS Code: 29372900