Exemestane , 98% , 107868-30-4
Synonym(s):
6-Methyleneandrosta-1,4-diene-3,17-dione;Exemestane
CAS NO.:107868-30-4
Empirical Formula: C20H24O2
Molecular Weight: 296.4
MDL number: MFCD00866994
EINECS: 643-090-2
Pack Size | Price | Stock | Quantity |
200mg | RMB89.60 | In Stock |
|
1g | RMB302.40 | In Stock |
|
5g | RMB1039.20 | In Stock |
|
others | Enquire |
PRODUCT Properties
Melting point: | 155.13°C |
Boiling point: | 453.7±45.0 °C(Predicted) |
Density | 1.13±0.1 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMSO: ≥20mg/mL |
form | powder |
color | white to off-white |
optical activity | [α]/D +250 to +300°, c = 1 in methanol |
InChI | InChI=1S/C20H24O2/c1-12-10-14-15-4-5-18(22)20(15,3)9-7-16(14)19(2)8-6-13(21)11-17(12)19/h6,8,11,14-16H,1,4-5,7,9-10H2,2-3H3/t14-,15-,16-,19+,20-/m0/s1 |
InChIKey | BFYIZQONLCFLEV-DAELLWKTSA-N |
SMILES | C1(=O)C=C2[C@](C)(C=C1)[C@]1([H])[C@]([H])([C@@]3([H])[C@@](CC1)(C)C(=O)CC3)CC2=C |
CAS DataBase Reference | 107868-30-4(CAS DataBase Reference) |
Description and Uses
Exemestane was launched in US and other countries for the treatment of estrogendependent tumors and postmenopausal breast cancer. It is a novel steroidal compound structurally related to the natural substrate for the biosynthesis of estrogen, androstanedione, and can be synthesized by methylidenation of androsta-1, 4-dien- 17beta-ol-3-one in 6 position then oxidation of the alcohol function. Exemestane is an irreversible inactivator of the aromatase enzyme system, so inducing in vivo a dose-related sustained suppression of serum estrogen and minimal endocrine activity. It is the first steroidal representative of the third-generation of orally active aromatase inhibitors with a highly potent and selective mechanism of action, displaying good tolerability and safety profile. In rats with DMBA-induced mammary tumors, 10 to 100 mglkg of exemestan administered po twice-daily for 4 weeks resulted in 76 to 88% regression. In women failing anti-estrogen therapy with tamoxifen, this agent has demonstrated high activity in locally advanced or metastatic disease. In addition, it may also have potential for breast cancer prevention.
antiinfective
Safety
Symbol(GHS) | GHS08,GHS09 |
Signal word | Danger |
Hazard statements | H360-H411 |
Precautionary statements | P201-P202-P273-P280-P308+P313-P391 |
Hazard Codes | T,N |
Risk Statements | 60-61-51 |
Safety Statements | 53-22-36/37-57 |
WGK Germany | 3 |
HS Code | 29372900 |
Hazardous Substances Data | 107868-30-4(Hazardous Substances Data) |