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LN7069252

Benzonatate , 98% , 104-31-4

CAS NO.:104-31-4

Empirical Formula: C30H53NO11

Molecular Weight: 603.74

MDL number: MFCD00072060

EINECS: 203-194-7

Pack Size Price Stock Quantity
5mg RMB1773.60 In Stock
10mg RMB2853.60 In Stock
25mg RMB5805.60 In Stock
50mg RMB8973.60 In Stock
100mg RMB13460.80 In Stock
200mg RMB20191.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Boiling point: 649.0±55.0 °C(Predicted)
Density  1.096±0.06 g/cm3(Predicted)
storage temp.  Refrigerator, under inert atmosphere
solubility  Chloroform (Slightly), Methanol (Slightly)
pka 2.20±0.39(Predicted)
form  Oil
color  Light Yellow to Light Brown
BCS Class 3?
CAS DataBase Reference 104-31-4(CAS DataBase Reference)

Description and Uses

Benzonatate is a reversible voltage-gated sodium channel blocker. It blocks Nav1.7 currents in a concentration- and voltage-dependent manner (IC50s = 5.9 and 1.4 μM at holding potentials of -100 and -70 mV, respectively) and inhibits action potential firing in catecholamine A differentiated (CAD) cells. Benzonatate also blocks 80% of Nav1.3 currents in N1E-115 cells when used at a concentration of 100 μM. In vivo, benzonatate (0.85 mg/min) reduces the frequency, but has no effect on the amplitude, of the cough reflex in anesthetized dogs. Formulations containing benzonatate have been used as antitussive agents for the treatment of coughs.

Antitussive

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H319-H335-H315
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362
Hazardous Substances Data 104-31-4(Hazardous Substances Data)
Toxicity LD50 oral in mouse: 400mg/kg

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