(±)-2-MethylArachidonoyl-2'-Fluoroethylamide(solutioninethanol) , ≥98% , 166100-39-6

Synonym(s):
2-Methyl-2′-fluoro AEA;Fluoromethanandamide;O-689

CAS NO.：166100-39-6

Empirical Formula: C23H38FNO

Molecular Weight: 363.55

MDL number: MFCD01862615

EINECS: 200-578-6

PRODUCT Properties

• Boiling point: 503.6±50.0 °C(Predicted)
• Density: 0.921±0.06 g/cm3(Predicted)
• Flash point: 14 °C
• storage temp.: −20°C
• solubility: DMF: >10 mg/ml; DMSO: >30 mg/ml; Ethanol: >100 mg/ml; Ethanol:PBS (1:2): 8.5 mg/ml; PBS (pH 7.2): <100 μg/ml
• pka: 14.98±0.46(Predicted)
• form: ethanol solution

Description and Uses

(±)-2-Methyl arachidonoyl-2''-fluoroethylamide (2-Methyl-2''-fluoro AEA) is an analog of anandamide (AEA) in which the alcohol of the ethanolamide group has been removed and replaced with a fluorine atom. This substitution confers considerably increased binding affinity for the CB₁ receptor (K_i = 5.7 nM in rat brain). It also confers additional selectivity, in that binding to CB₂ is decreased relative to AEA. However, the in vivo activity of 2-fluoro AEA is enhanced much less than the binding affinity, because the analog remains a good substrate for FAAH and is rapidly hydrolyzed by this enzyme. 2-Methyl-2''-fluoro AEA is further modified by the addition of an α-methyl group at the C-2 position of arachidonic acid. This substitution confers enhanced metabolic stability. 2-Methyl-2''-fluoro AEA can fully substitute for Δ⁹-THC in animal self-administration tests, whereas AEA and 2-fluoro AEA cannot.

Met-F-AEA is a metabolically stable anandamine analogue. Met-F-AEA inhibits cell growth by activating apoptosis. Met-F-AEA has antitumor activity[1].

Safety

• Symbol(GHS): GHS02,GHS07
• Signal word: Danger
• Hazard statements: H225-H319
• Precautionary statements: P210-P305+P351+P338
• Hazard Codes: F,Xi
• Risk Statements: 11-36/37/38
• Safety Statements: 7-16-26-36
• RIDADR: UN 1170 3/PG 2
• WGK Germany: 1