Arachidonoyl-2'-Fluoroethylamide(solutioninethanol) , ≥98% , 166100-37-4

CAS NO.：166100-37-4

Empirical Formula: C22H36FNO

Molecular Weight: 349.53

MDL number: MFCD02259376

PRODUCT Properties

• Boiling point: 496.0±45.0 °C(Predicted)
• Density: 0.925±0.06 g/cm3(Predicted)
• solubility: DMF: 10 mg/ml; DMSO: 7 mg/ml; Ethanol: 15 mg/ml; Ethanol:PBS (1:1): 8 mg/ml
• pka: 15.24±0.46(Predicted)

Description and Uses

Arachidonoyl-2'-fluoroethylamide (2-fluoro AEA) is an analog of anandamide in which the alcohol of the ethanolamide group has been removed and replaced with a fluorine atom. This substitution adds considerably increased binding affinity for the CB₁ receptor (K_is = 26.7 and 908 nM for CB₁ and CB₂, respectively). It also contributes additional selectivity, in that binding to CB₂ is decreased relative to AEA.¹ However, the in vivo activity of 2-fluoro AEA is enhanced much less than the binding affinity, because the analog remains a good substrate for FAAH and is rapidly hydrolyzed by this enzyme.

Arachidonoyl-2'-fluoroethylamide is a CB1 receptor agonist and an analog of Anandamide (A637220), which is an endogenous cannabinoid and TRPV1 receptor agonist.

Safety

• Symbol(GHS): GHS02,GHS07
• Signal word: Danger
• Hazard statements: H225-H319
• Precautionary statements: P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501