(±)12-HETE(solutioninethanol) , ≥95% , 71030-37-0

CAS NO.：71030-37-0

Empirical Formula: C20H32O3

Molecular Weight: 320.47

MDL number: MFCD00065826

PRODUCT Properties

• Boiling point: 487.7±45.0 °C(Predicted)
• Density: 0.984±0.06 g/cm3(Predicted)
• storage temp.: Store at -20°C
• solubility: 0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): 0.8 mg/ml
• form: Liquid
• pka: 4.75±0.10(Predicted)
• color: Colorless to light yellow

Description and Uses

(±)12-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of arachidonic acid. The biological activity of (±)12-HETE is similar to that of its constituent enantiomers (Item Nos. 34560 and 34570). It aggregates neutrophils with an EC₅₀ value of 40 nM.

12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway[1].12-HETE has both anti-thrombotic and pro-thrombotic effects[2]. 12-HETE is a neuromodulator[3].

Safety

• Symbol(GHS): GHS02
• Signal word: Danger