~100 μg/mLinethanol,≥95%(HPLC) , 54397-83-0

Synonym(s):
(S)-12-HETE

CAS NO.：54397-83-0

Empirical Formula: C20H32O3

Molecular Weight: 320.47

MDL number: MFCD00036916

EINECS: 200-578-6

PRODUCT Properties

• Boiling point: 487.7±45.0 °C(Predicted)
• Density: 0.984±0.06 g/cm3(Predicted)
• Flash point: 14 °C
• storage temp.: -20°C
• solubility: 0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml
• form: Liquid.
• pka: 4.75±0.10(Predicted)
• color: Colorless to light yellow
• BRN: 2656104

Description and Uses

12(S)-HETE is the predominant lipoxygenase product of mammalian platelets. It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix at 0.1 μM.

12(S)-HETE MaxSpec^® standard is a quantitative grade standard of 12(S)-HETE that has been prepared specifically for mass spectrometry or any application where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This 12(S)-HETE MaxSpec^® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

A fatty acid metabolite of arachidonic acid (A765000). Potential biomarker for asthma monitoring and diagnosis. Stimulates protein kinase C-mediated release of cathepsin B from malignant cells. Used in the study of mechanisms controlling cell cycle arrest and induction of apoptosis in prostate cancer cells via 12-lipoxygenase inhibition..

Safety

• Symbol(GHS): GHS02,GHS07
• Signal word: Danger
• Hazard statements: H225-H319
• Precautionary statements: P210-P305+P351+P338
• Hazard Codes: F,Xi
• Risk Statements: 11-36/37/38
• Safety Statements: 7-16-26-36
• RIDADR: UN 1170 3/PG 2
• WGK Germany: 1
• F: 8-10-23