Minocycline , 95+% , 10118-90-8
CAS NO.：10118-90-8
Empirical Formula: C23H27N3O7
Molecular Weight: 457.48
MDL number: MFCD00072105
EINECS: 800-277-5
| Pack Size | Price | Stock | Quantity |
| 100mg | RMB107.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| alpha | D25 -166° (c = 0.524) |
| Boiling point: | 563.31°C (rough estimate) |
| Density | 1.3283 (rough estimate) |
| refractive index | 1.6500 (estimate) |
| solubility | Methanol (Slightly) |
| form | Solid |
| pka | pKa 2.8 (Uncertain);5.0 (Uncertain);7.8 (Uncertain);9.5 (Uncertain) |
| color | Yellow to Dark Orange |
| Water Solubility | 52g/L(25 ºC) |
| Stability: | Light Sensitive |
Description and Uses
An important antibiotic produced by semisynthesis from demeclocycline is minocycline. It is much more lipophilic than its precursors, gives excellent blood levels following oral administration (90–100% available),and can be given once a day. Its absorption is lowered by approximately 20% when taken with food or milk. It is less dependent on active uptake mechanisms and has a somewhat broader antimicrobial spectrum. It also, apparently, is less painful on IM or IV injection, but it has vestibular toxicities (e.g., vertigo, ataxia, and nausea) not generally shared by other tetracyclines.
Minocycline is used for the same indications as other antibiotics of the tetracycline series. In a few cases, it is tolerated worse than other tetracyclines, and in particular, it has an effect on the vestibular apparatus. In addition, as seen already from the synthesis scheme, it is much more expensive than other tetracyclines, which are synthesized in a purely microbiological manner. Synonyms of this drug are clinocin, minocyn, vectrin, and others.
Safety
| Symbol(GHS) |   GHS08,GHS07 |
| Signal word | Warning |
| Hazard statements | H319-H361-H362 |
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501-P264-P280-P305+P351+P338-P337+P313P-P201-P260-P263-P264-P270-P308+P313 |
