11β-13,14-dihydro-15-ketoProstaglandinF2α , ≥98% , 107615-77-0

CAS NO.：107615-77-0

Empirical Formula: C20H34O5

Molecular Weight: 354.48

MDL number: MFCD00216071

PRODUCT Properties

• solubility: 10 mM Na2CO3: >6.5 mg/ml (from PGF2a); DMF: >100 mg/ml (from PGF2a); DMSO: >100 mg/ml (from PGF2a); Ethanol: >100 mg/ml (from PGF2a); PBS pH 7.2: >10 mg/ml (from PGF2a)

Description and Uses

11β-13,14-dihydro-15-keto PGF_2α is a metabolite of PGD₂ in the 15-hydroxy PGDH pathway.^1,2 Infusion or inhalation of tritiated PGD₂ in normal males results in the appearance of peak levels of both 11β-PGF_2α, as the immediate product, and 11β-13,14-dihydro-15-keto PGF_2α in the plasma within 10 minutes.¹ Homogenates of human lung metabolize PGD₂ first to 11β-PGF_2α and then to 11β-15-keto-PGF_2α in the presence of NAD⁺, but not 11β-13,14-dihydro-15-keto PGF_2α.² Guinea pig liver and kidney homogenates metabolize PGD₂ to 11β-13,14-dihydro-15-keto PGF_2α, via 11β-PGF_2α, in the presence of NAD⁺ and NADP⁺.²

Safety

• Symbol(GHS): GHS02,GHS07
• Signal word: Danger
• Hazard statements: H225-H319-H336
• Precautionary statements: P210-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P337+P313-P370+P378-P403+P233-P403+P235-P405-P501