LN3536441
ETIZOLAM , 98.00% , 40054-69-1
CAS NO.：40054-69-1
Empirical Formula: C17H15ClN4S
Molecular Weight: 342.85
MDL number: MFCD00867532
EINECS: 662-368-4
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 147-148℃ |
| Boiling point: | 264.5°C (rough estimate) |
| Density | 1.43 |
| refractive index | 1.6100 (estimate) |
| Flash point: | 9°C |
| storage temp. | -20°C |
| solubility | DMF: 5 mg/ml; DMSO: 5 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml |
| form | A neat solid |
| pka | 2.37±0.40(Predicted) |
Description and Uses
Etizolam is a potent thienodiazepine anxiolytic closely related to brotizolam. Pharmacologically, however, its profile most resembles that of diazepam.
Etilozam is a a thienodiazepine benzodiazepine derivative, and has amnesic, anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. Etizolam is an anxiolytic related to that of the classic benzodiazepines. Etizolam has effect on monoamine metabolism in brain. Etilozam can be used for the short-term treatment of insomnia, anxiety or panic attacks.
Safety
| Symbol(GHS) |    GHS02, GHS06, GHS08 |
| Signal word | Danger |
| Hazard statements | H225-H301+H311+H331-H370 |
| Precautionary statements | P210-P260-P280-P301+P310-P311 |
| Hazard Codes | F,T |
| Risk Statements | 11-23/24/25-39/23/24/25 |
| Safety Statements | 7-16-36/37-45 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 1 |
| Toxicity | LD50 in male, female rats, male, female mice (mg/kg): 3619, 3509, 4358, 4258 orally; 865, 825, 830, 783 i.p.; >5000 s.c. (Tsumagari) |
