≥98%(HPLC) , 105219-56-5

Synonym(s):
3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-(4-morpholinyl)-1-propanone;Apafant;WEB 2086BS

CAS NO.：105219-56-5

Empirical Formula: C22H22ClN5O2S

Molecular Weight: 455.96

MDL number: MFCD00865271

PRODUCT Properties

• Melting point: 186-188°C
• Boiling point: 720.2±70.0 °C(Predicted)
• Density: 1.48
• storage temp.: 2-8°C
• solubility: DMSO: soluble10mg/mL (clear solution)
• pka: 2.36±0.40(Predicted)
• form: powder
• color: white to beige
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Description and Uses

WEB-2086 (105219-56-5) is a potent and selective antagonist of the platelet activating factor (PAF) receptor (Ki = 16.3 nM).1?Displays an activity profile which includes antiinflammatory, antiangiogenesis and anticancer activity.2?Along with leukotriene antagonists, WEB-2086 cooperatively provides a robust antiinflammatory effect regulating PMNL migration and edema formation.3?Displays analgesic effects in animal models of neuropathic pain.4?Active in vivo.

Platelet activating factor (PAF) antagonist.

Safety

• Symbol(GHS): GHS08
• Signal word: Warning
• Hazard statements: H361
• Precautionary statements: P201-P202-P281-P308+P313-P405-P501
• WGK Germany: 3
• Toxicity: LD50 in mice (mg/kg): 540 i.v.; 4600 orally (Casals-Stenzel)