PK11195 , ≥98% , 85340-56-3

Synonym(s):
1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide

CAS NO.：85340-56-3

Empirical Formula: C21H21ClN2O

Molecular Weight: 352.86

MDL number:

Description and Uses

PK 11195 is a high affinity peripheral benzodiazepine receptor (PBR) ligand. PK 11195 has been shown to regulate protein phosphorylation in rat brain mitochondria under control of Ca2+. PK11195 promotes mitochondrial apoptosis and blocks P-glycoprotein (Pgp)-mediated drug efflux to chemosensitize cancer cells.