85532-75-8
Synonym(s):
PK11195 - CAS 85532-75-8 - Calbiochem;TSPO Activator II, Mitochondrial Translocator Protein Activator II, PK 11195, PK-11195, PK11195
| Pack Size | Price | Stock | Quantity |
| 10mg | RMB1155.33 | In Stock |
|
| 50mg | RMB3985.97 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Boiling point: | 511.7±45.0 °C(Predicted) |
| Density | 1.179±0.06 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 15 mg/ml). |
| form | White crystalline powder. |
| pka | 1.76±0.50(Predicted) |
| color | White |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored under nitrogen or argon at -20° for up to 1 month. |
Description and Uses
PK-11195 (85532-75-8) is a selective and potent peripheral benzodiazepine receptor, PBR (or TSPO, translocator protein) antagonist.1,2 It has been shown to chemosensitize tumor cells to a variety of chemotherapeutic agents via PBR-independent pathways.3,4 PK-11195 is also able to induce apoptosis in a variety of cell lines.5-7
PK 11195 is a high affinity peripheral benzodiazepine receptor (PBR) ligand. PK 11195 has been shown to regulate protein phosphorylation in rat brain mitochondria under control of Ca2+. PK11195 promotes mitochondrial apoptosis and blocks P-glycoprotein (Pgp)-mediated drug efflux to chemosensitize cancer cells.
Safety
| WGK Germany | 3 |
| RTECS | NW6987000 |
