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S8935314

85532-75-8

Synonym(s):
PK11195 - CAS 85532-75-8 - Calbiochem;TSPO Activator II, Mitochondrial Translocator Protein Activator II, PK 11195, PK-11195, PK11195

CAS NO.:85532-75-8

Empirical Formula: C21H21ClN2O

Molecular Weight: 352.86

MDL number: MFCD00069334

Pack Size Price Stock Quantity
10mg RMB1155.33 In Stock
50mg RMB3985.97 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Boiling point: 511.7±45.0 °C(Predicted)
Density  1.179±0.06 g/cm3(Predicted)
storage temp.  Store at RT
solubility  Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 15 mg/ml).
form  White crystalline powder.
pka 1.76±0.50(Predicted)
color  White
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored under nitrogen or argon at -20° for up to 1 month.

Description and Uses

PK-11195 (85532-75-8) is a selective and potent peripheral benzodiazepine receptor, PBR (or TSPO, translocator protein) antagonist.1,2 It has been shown to chemosensitize tumor cells to a variety of chemotherapeutic agents via PBR-independent pathways.3,4 PK-11195 is also able to induce apoptosis in a variety of cell lines.5-7

PK 11195 is a high affinity peripheral benzodiazepine receptor (PBR) ligand. PK 11195 has been shown to regulate protein phosphorylation in rat brain mitochondria under control of Ca2+. PK11195 promotes mitochondrial apoptosis and blocks P-glycoprotein (Pgp)-mediated drug efflux to chemosensitize cancer cells.

Safety

WGK Germany  3
RTECS  NW6987000

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