PRODUCT Properties
| Melting point: | 180-190° (dec) |
| alpha | D22 +7° (c = 2) |
| Boiling point: | 608.13°C (rough estimate) |
| Density | 1.4252 (rough estimate) |
| refractive index | 1.6300 (estimate) |
| pka | 12.53±0.10(Predicted) |
Description and Uses
Destomycin A was found in the culture broth of Streptomyces rimofaciens by Meiji Seika Kaisha in 1965 in the course of screening for water-soluble and basic antibiotics, such as aminoglycosides. It shows activity against a variety of gram-positive and gram-negative bacteria as well as fungi and, more interestingly, against helminths. Destomycin A has been used to treat helminth infections in swine and poultry.
Demycin A is currently mainly used in feed to prevent and control digestive tract parasites in chickens and pigs.
Safety
| Toxicity | LD50 in mice (after 2-week observation) (mg/kg): 5-10 i.v.; 50-100 orally (Kondo, 1965) |
