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LN-240030

AG 490 , 134036-52-5

Synonym(s):
2-Cyano-3-(3,4-dihydroxyphenyl)-N-(benzyl)-2-propenamide;2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide

CAS NO.:134036-52-5

Empirical Formula: C17H14N2O3

Molecular Weight: 294.3

MDL number: MFCD00209833

Update time: 2023-04-23

PRODUCT Properties

Melting point: 215
Boiling point: 615.2±55.0 °C(Predicted)
Density  1.337±0.06 g/cm3(Predicted)
storage temp.  −20°C
solubility  ethanol: 5 mg/mL
pka 8.82±0.35(Predicted)
form  solid
color  yellow
CAS DataBase Reference 134036-52-5(CAS DataBase Reference)

Description and Uses

A potent and specific inhibitor of the Jak-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. AG-490 is cell permeable and is active in vivo.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38-50-25
Safety Statements  26-36-61-45
WGK Germany  1
Hazard Note  Irritant/Keep Cold under -20C
HS Code  2926907090

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