LN-240030
AG 490 , 134036-52-5
Synonym(s):
2-Cyano-3-(3,4-dihydroxyphenyl)-N-(benzyl)-2-propenamide;2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide
Update time: 2023-04-23
PRODUCT Properties
| Melting point: | 215 |
| Boiling point: | 615.2±55.0 °C(Predicted) |
| Density | 1.337±0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | ethanol: 5 mg/mL |
| pka | 8.82±0.35(Predicted) |
| form | solid |
| color | yellow |
Description and Uses
A potent and specific inhibitor of the Jak-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. AG-490 is cell permeable and is active in vivo.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38-50-25 |
| Safety Statements | 26-36-61-45 |
| WGK Germany | 1 |
| Hazard Note | Irritant/Keep Cold under -20C |
| HS Code | 2926907090 |
