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LN4729349

AG-213 , ≥98% , 122520-86-9

CAS NO.:122520-86-9

Empirical Formula: C10H8N2O2S

Molecular Weight: 220.25

MDL number: MFCD00133902

Pack Size Price Stock Quantity
5mg RMB600.00 In Stock
10mg RMB1136.00 In Stock
25mg RMB2388.00 In Stock
50mg RMB4224.80 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 213 °C
Boiling point: 474.5±55.0 °C(Predicted)
Density  1.512±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  DMSO: 50 mg/mL, clear, orange
pka 8.82±0.10(Predicted)
form  Orange solid.

Description and Uses

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds that act as PTK blockers. PTK inhibitors which preferentially inhibit the epidermal growth factor (EGF) receptor kinase block EGF-dependent cell proliferation. AG-213 is an inhibitor of epidermal growth factor (EGF) receptor kinase with an IC50 value of 2.4 μM in the human epidermoid carcinoma cell line A431.

Tyrphostin 47 is a potent inhibitor of EGFR kinase activity.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
10

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