BD3502348
Pyrazine-2-carbonylchloride , 98% , 19847-10-0
CAS NO.：19847-10-0
Empirical Formula: C5H3ClN2O
Molecular Weight: 142.54
MDL number: MFCD00792886
EINECS: 243-367-4
| Pack Size | Price | Stock | Quantity |
| 5g | RMB3367.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 41°C |
| Boiling point: | 214.5±20.0 °C(Predicted) |
| Density | 1.393±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | -2.50±0.10(Predicted) |
| Water Solubility | Reacts with water. |
| Sensitive | Moisture Sensitive |
Description and Uses
2-Pyrazinecarbonyl Chloride is an intermediate used in the synthesis of (S)-N-[1-(3-Hydroxy-3-methylbutanamido)-1-oxo-3-phenylpropan-2yl]pyrazine-2-carboxamide (H805105), which is an impurity of bortezomib (B675700), which is the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.
Safety
| Symbol(GHS) |  GHS05 |
| Hazard statements | H314-H318 |
| Precautionary statements | P260h-P301+P330+P331-P303+P361+P353-P305+P351+P338-P405-P501a |
| Risk Statements | 34 |
| Safety Statements | 26-36/37/39-45 |
| RIDADR | 3265 |
| HazardClass | 8 |
| PackingGroup | II |
| HS Code | 2933998090 |
