Azithromycin , Analysis standard , 83905-01-5

Synonym(s):
N-Methyl-11-aza-10-deoxo-10-dihydroerythromycin A;Azithromycin;Azithromycin dihydrate;CP 62,993;CP-62993

CAS NO.：83905-01-5

Empirical Formula: C38H72N2O12

Molecular Weight: 748.98

MDL number: MFCD00873574

EINECS: 617-500-5

PRODUCT Properties

• Melting point: 113-115°C
• alpha: D20 -37° (c = 1 in CHCl3)
• Boiling point: 822.1±65.0 °C(Predicted)
• Density: 1.18±0.1 g/cm3(Predicted)
• storage temp.: Sealed in dry,2-8°C
• solubility: Practically insoluble in water, freely soluble in anhydrous ethanol and in methylene chloride.
• form: Solid
• pka: pKa 8.74 (H2O t=25 I=0.167) (Uncertain);9.45(H2O t=25 I=0.167) (Uncertain)
• color: White to Off-White
• optical activity: [α]/D 45±2°, c = 1% in ethanol
• BCS Class: 4
• Stability: Stable. Incompatible with strong oxidizing agents.

Description and Uses

Azithromycin was the first of the azalides and was designed to improve the stability and biological half-life of erythromycin A, as well as improve activity against Gram negative bacteria. Azithromycin is a long-acting macrolide antibiotic structurally related to erythromycin A (EA), having a methyl-substituted nitrogen at position 9a in the aglycone ring.

Azithromycin is an azalide macrolide antibiotic.

Safety

• Symbol(GHS): GHS08
• Signal word: Danger
• Hazard statements: H317-H334
• Precautionary statements: P261-P280-P342+P311
• Hazard Codes: Xi,Xn
• Risk Statements: 42/43
• Safety Statements: 22-36/37-45
• WGK Germany: 2
• RTECS: RN6960000
• HS Code: 29419090
• Toxicity: LD50 oral in rat: > 2gm/kg