(2R,4S)-Ethyl5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoatehydrochloride , 95% , 149690-12-0

CAS NO.：149690-12-0

Empirical Formula: C20H26ClNO2

Molecular Weight: 347.879

MDL number: MFCD27955986

EINECS: 695-675-7

Pack Size	Price	Stock	Quantity
1g	RMB246.40	In Stock
5g	RMB743.20	In Stock
10g	RMB1244.80	In Stock
25g	RMB2432.80	In Stock
100g	RMB5995.20	In Stock
others			Enquire

Update time: 2022-07-08

PRODUCT Properties

Melting point:	155 - 162°C
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
color	White to Off-White
Stability:	Hygroscopic
InChI	InChI=1/C20H25NO2.ClH/c1-3-23-20(22)15(2)13-19(21)14-16-9-11-18(12-10-16)17-7-5-4-6-8-17;/h4-12,15,19H,3,13-14,21H2,1-2H3;1H/t15-,19+;/s3
InChIKey	MYJTZLYRAWUSLB-MTPCZXHRNA-N
SMILES	C(C1C=CC(C2C=CC=CC=2)=CC=1)[C@@H](N)C[C@@H](C)C(=O)OCC.Cl \|&1:13,16,r\|

Description and Uses

(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride is used as a reagent in the synthesis of LCZ696, an angiotensin II receptor and neprilysin receptor dual inhibitor. (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride is also used as a reagent in the preparation of novel NEP inhibitor prodrugs for the treatment of hypertension and cardiovascular diseases.

Safety

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

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