(2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid , 95% , 1012341-50-2

CAS NO.：1012341-50-2

Empirical Formula: C23H29NO4

Molecular Weight: 383.48

MDL number: MFCD27955981

EINECS: 1592732-453-0

PRODUCT Properties

• Melting point: 145-147°C
• Boiling point: 582.6±50.0 °C(Predicted)
• Density: 1.115±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Sonicated)
• pka: 4?+-.0.23(Predicted)
• form: Solid
• color: White to Off-White
• InChI: InChI=1/C23H29NO4/c1-16(21(25)26)14-20(24-22(27)28-23(2,3)4)15-17-10-12-19(13-11-17)18-8-6-5-7-9-18/h5-13,16,20H,14-15H2,1-4H3,(H,24,27)(H,25,26)/t16-,20+/s3
• InChIKey: YNELJETWNMPEEH-OXDNQSQGNA-N
• SMILES: C(O)(=O)[C@H](C)C[C@H](NC(OC(C)(C)C)=O)CC1=CC=C(C2=CC=CC=C2)C=C1 |&1:3,6,r|

Description and Uses

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid is a pharmaceutical intermediate compound that can be used to synthesize Sacubitril, a neprilysin inhibitor used as an adjuvant drug in combination with valsartan to reduce the risk of cardiovascular death and heart failure hospitalization in patients with chronic heart failure (NYHA class II-IV) and reduced ejection fraction.

(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic Acid is a useful building block in the synthesis of various pharmaceuticals. Could be useful for treating bacterial infectious disease.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338