1-(2-Deoxy-2-fluoro-b-D-arabinofuranosyl)-5-iodouracil , 98% , 69123-98-4

Synonym(s):
1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodo-2,4(1H,3H)-Pyrimidinedione;FIAU

CAS NO.：69123-98-4

Empirical Formula: C9H10FIN2O5

Molecular Weight: 372.09

MDL number: MFCD00866922

EINECS: 1312995-182-4

PRODUCT Properties

• Melting point: 216-217°C
• Density: 2.18±0.1 g/cm3(Predicted)
• storage temp.: -20°C
• solubility: DMSO: soluble5mg/mL, clear (warmed)
• form: powder
• pka: 7.94±0.10(Predicted)
• color: white to beige
• Merck: 14,4069
• InChIKey: IPVFGAYTKQKGBM-BYPJNBLXSA-N

Description and Uses

Fialuridine (FIAU) is one of a series of 2'-fluoro-substituted arabinosyl pyrimidine nucleosides that have demonstrated potent antiviral activities against a number of clinically important viruses, including hepatitis B virus (HBV). Analogs of FIAU have been shown to inhibit viral replication in the woodchuck and duck models of HBV infection. Although the mechanism of the anti-HBV activity is not well understood, evidence suggests that the triphosphate analog of FIAU is a potent inhibitor of HBV DNA polymerase activity. During early clinical investigation FIAU showed much promise as an antiHBV drug because it markedly reduced the level of HBV DNA in the serum of patients with chronic hepatitis B. However, clinical trials were terminated after adverse events occurred following oral administration of FIAU (0.1 and 0.25 mg/kg of body weight per day) for more than 2 months. The mechanism of the unexpected delayed toxicity is unresolved.

Fialuridine has been used in the selection of clones.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• Safety Statements: 24/25
• WGK Germany: 3
• RTECS: YQ9512500
• HS Code: 29349990