5-Ethyl-3-methyl-5-phenylimidazolidine-2,4-dione , 98% , 50-12-4

Synonym(s):
(±)-5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione;(±)-5-Ethyl-3-methyl-5-phenylhydantoin;(±)-Mephenytoin;(S)-(+)-5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione;(S)-(+)-5-Ethyl-3-methyl-5-phenylhydantoin

CAS NO.：50-12-4

Empirical Formula: C12H14N2O2

Molecular Weight: 218.25

MDL number: MFCD00270025

EINECS: 200-012-8

PRODUCT Properties

• Melting point: 135-138 °C
• Boiling point: 358.94°C (rough estimate)
• Density: 1.154±0.06 g/cm3 (20 ºC 760 Torr)
• refractive index: 1.6660 (estimate)
• storage temp.: 2-8°C
• solubility: DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
• form: solid
• pka: pKa 8.1 (Uncertain)
• color: off-white

Description and Uses

Mephenytoin is N-methylated at position 3 with an ethyl group replacing one of the phenyl substituents at position 5. It is indicated for focal and jacksonian seizures in patients refractory to less toxic AEDs. Mephenytoin produces more sedation than phenytoin and should be used only when safer drugs have failed, because it is associated with an increased incidence of serious toxicities, such as severe rash, agranulocytosis, and hepatitis. Its N-desmethyl metabolite, 5-phenyl- 5-ethylhydantoin, contributes to both efficacy and toxicity for mephenytoin. The drug is no longer commercially available inside but is still available outside the United States.

rac-Mephenytoin is an anticonvulsant agent.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• Hazard Codes: Xn
• Risk Statements: 22-36/37/38
• Safety Statements: 26-36
• WGK Germany: 2
• HS Code: 2933210000
• Toxicity: LD50 i.p. in mice: 300 mg/kg (Dzhagatspanyan)