5-Ethyl-3-methyl-5-phenylimidazolidine-2,4-dione , 98% , 50-12-4
Synonym(s):
(±)-5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione;(±)-5-Ethyl-3-methyl-5-phenylhydantoin;(±)-Mephenytoin;(S)-(+)-5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione;(S)-(+)-5-Ethyl-3-methyl-5-phenylhydantoin
CAS NO.:50-12-4
Empirical Formula: C12H14N2O2
Molecular Weight: 218.25
MDL number: MFCD00270025
EINECS: 200-012-8
Pack Size | Price | Stock | Quantity |
50mg | RMB996.00 | In Stock |
|
100mg | RMB1298.40 | In Stock |
|
250mg | RMB1947.20 | In Stock |
|
1g | RMB4866.40 | In Stock |
|
others | Enquire |
PRODUCT Properties
Melting point: | 135-138 °C |
Boiling point: | 358.94°C (rough estimate) |
Density | 1.154±0.06 g/cm3 (20 ºC 760 Torr) |
refractive index | 1.6660 (estimate) |
storage temp. | 2-8°C |
solubility | DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly) |
form | solid |
pka | pKa 8.1 (Uncertain) |
color | off-white |
CAS DataBase Reference | 50-12-4(CAS DataBase Reference) |
EPA Substance Registry System | Mephenytoin (50-12-4) |
Description and Uses
Mephenytoin is N-methylated at position 3 with an ethyl group replacing one of the phenyl substituents at position 5. It is indicated for focal and jacksonian seizures in patients refractory to less toxic AEDs. Mephenytoin produces more sedation than phenytoin and should be used only when safer drugs have failed, because it is associated with an increased incidence of serious toxicities, such as severe rash, agranulocytosis, and hepatitis. Its N-desmethyl metabolite, 5-phenyl- 5-ethylhydantoin, contributes to both efficacy and toxicity for mephenytoin. The drug is no longer commercially available inside but is still available outside the United States.
rac-Mephenytoin is an anticonvulsant agent.
Safety
Symbol(GHS) | GHS07 |
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
Hazard Codes | Xn |
Risk Statements | 22-36/37/38 |
Safety Statements | 26-36 |
WGK Germany | 2 |
HS Code | 2933210000 |
Hazardous Substances Data | 50-12-4(Hazardous Substances Data) |
Toxicity | LD50 i.p. in mice: 300 mg/kg (Dzhagatspanyan) |