PRODUCT Properties
| Boiling point: | 362.36°C (rough estimate) |
| Density | 1.0490 (rough estimate) |
| refractive index | 1.5290 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| pka | pKa 6.8(H2O,I=0.1) (Uncertain) |
Description and Uses
Procarbazine was initially synthesized as an MAO inhibitor. However, it was discovered later on that it has ability to act as an alkylating agent and inhibit DNA, RNA, and protein synthesis. Along with this, there is an opinion that procarbazine accumulates in cancerous tissue and generates peroxide and hydroperoxide radicals in cells, which imitates the effect of ionizing radiation. It is used for malignant tumors of lymphatic tissue, brain tumors, lung tumors, and Hodgkin’s disease. A synonym of this drug is natulan.
Safety
| Symbol(GHS) |   GHS07,GHS08 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335-H351-H361 |
| Precautionary statements | P261-P305+P351+P338 |
| Toxicity | A substituted hydrazine developed and used as an antineoplastic agent. It has been found to be carcinogenic in several species, the mechanism being, presumably and by analogy with 1,2-dimethyl hydrazine, the release of the methyl carbonium ion. This compound is also known to be immunosuppressive and to have adverse effects on the reproductive system. |
