Dacarbazine , ≥98% , 4342-03-4

Synonym(s):
5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide;Dacarbazine;DTIC

CAS NO.：4342-03-4

Empirical Formula: C6H10N6O

Molecular Weight: 182.18

MDL number: MFCD00057167

EINECS: 224-396-1

PRODUCT Properties

• Melting point: 199-205°C
• Boiling point: 315.57°C (rough estimate)
• Density: 1.3206 (rough estimate)
• refractive index: 1.7500 (estimate)
• storage temp.: 2-8°C
• solubility: Slightly soluble in water and in anhydrous ethanol, practically insoluble in methylene chloride.
• pka: pKa 4.42 (Uncertain)
• form: powder
• color: Off-White to Light Yellow
• Water Solubility: Slightly soluble in water, DMSO and ethanol /n
• Merck: 14,2798
• LogP: -0.240
• CAS DataBase Reference: 4342-03-4(CAS DataBase Reference)
• IARC: 2B (Vol. 26, Sup 7) 1987
• EPA Substance Registry System: Dacarbazine (4342-03-4)

Description and Uses

Dacarbazine is nevertheless considered the first representative of the series of triazene derivatives. It has been shown that it is an alkylating agent, and thus this drug inhibits RNA and protein synthesis to a greater degree than DNA. Dacarbazine is used intravenously for Hodgkin’s disease, soft-tissue sarcoma, and metastatic melanoma. A synonym of this drug is diticene.

progestogen

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Danger
• Hazard statements: H302+H312+H332-H315-H319-H335-H340-H350
• Precautionary statements: P201-P261-P280-P301+P312+P330-P305+P351+P338-P308+P313
• Hazard Codes: T,Xi,Xn
• Risk Statements: 45-46-20/21/22-36/37/38
• Safety Statements: 53-36/37/39-45-37/39-36-26
• WGK Germany: 3
• RTECS: NI3950000
• HS Code: 29349990
• Hazardous Substances Data: 4342-03-4(Hazardous Substances Data)