Zileuton , ≥98%(HPLC) , 111406-87-2

Synonym(s):
(±)-N-hydroxy-N-(1-benzo[b]thien-2-ylethyl)urea;Zileuton

CAS NO.：111406-87-2

Empirical Formula: C11H12N2O2S

Molecular Weight: 236.29

MDL number: MFCD00866097

EINECS: 601-087-3

PRODUCT Properties

• Melting point: 157-158°C
• Boiling point: 449.4±47.0 °C(Predicted)
• Density: 1.401±0.06 g/cm3(Predicted)
• storage temp.: room temp
• solubility: DMSO: ≥20mg/mL at ~60°C (warm up to 60 C for 5min)
• pka: pKa 10.3(H2O t undefined I undefined) (Uncertain)
• form: powder
• color: white to off-white
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Description and Uses

Zileuton is a reversible 5-lipoxygenase (5-LO) inhibitor. It inhibits 5-LO activity in rat basophilic leukemia-1 (RBL-1) cell supernatant with an IC₅₀ value of 0.5 μM. Zileuton inhibits leukotriene B₄ (LTB₄; ) production induced by the calcium ionophore A23187 in purified human peripheral blood polymorphonuclear leukocytes (PMNLs; IC₅₀ = 0.6 μM). Zileuton (10 mg/kg, p.o.) prevents antigen challenge-induced increases in specific lung resistance in a sheep model of asthma at 4 to 8 hours post-challenge following administration 2 hours pre-challenge. Formulations containing zileuton have been used in the prophylaxis and chronic treatment of asthma.

An inhibitor of 5-lipoxygenase, the initial enzyme in the biosynthesis of leukotrienes from Arachidonic Acid. Used as an antiasthmatic.

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Warning
• Hazard statements: H302-H361d
• Precautionary statements: P202-P264-P270-P280-P301+P312-P308+P313
• Hazard Codes: Xn
• Risk Statements: 22-36
• Safety Statements: 26
• WGK Germany: 1
• HS Code: 2934990002