3′-Azido-3′-deoxythymidine , 10mMinDMSO , 30516-87-1
Synonym(s):
3′-Azido-3′-deoxythymidine;Azidothymidine;AZT;ZDV;Zidovudine
CAS NO.：30516-87-1
Empirical Formula: C10H13N5O5
Molecular Weight: 283.24
MDL number: MFCD00006536
EINECS: 623-849-4
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB159.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 113-115 °C (lit.) |
| Boiling point: | 410.43°C (rough estimate) |
| alpha | D25 +99° (c = 0.5 in water) |
| Density | 1.3382 (rough estimate) |
| refractive index | 47 ° (C=1, H2O) |
| Flash point: | 9℃ |
| storage temp. | 2-8°C |
| solubility | H2O: 50 mg/mL |
| pka | pKa 9.53(H2O
t = 25.0±0.1
I = 0.00) (Uncertain) |
| form | Powder |
| color | White to Off-white |
| Water Solubility | 1-5 g/100 mL at 17 ºC |
| Sensitive | Light Sensitive & Hygroscopic |
| Merck | 14,10123 |
| BRN | 3595791 |
| BCS Class | 1,3 |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| InChIKey | HBOMLICNUCNMMY-BWZBUEFSSA-N |
| CAS DataBase Reference | 30516-87-1(CAS DataBase Reference) |
| IARC | 2B (Vol. 76) 2000 |
| EPA Substance Registry System | Thymidine, 3'-azido-3'-deoxy- (30516-87-1) |
Description and Uses
Zidovudine, also known as azidothymidine (AZT), is an antiviral agent acting via reverse transcnptase inhibition. It was first launched in the U.K. and subsequently introduced in over a dozen countries for the management of severe manifestations of HIV infection. In patients with AIDS and ARC, zidovudine reduces the risk of opportunistic infections and prolongs survival time. In symptom-free patients it shows promise in halting further immunological deterioration.
Zidovudine is an antiretroviral drug that is clinically active against HIV-1 and is intended
to treat HIV-infected patients. Zidovudine is an analog of thymidine that inhibits replication of the AIDS virus. It also turned into mono-, di-, and triphosphates by the same cellular enzymes that catalyze phosphorylation of thymidine and thymidine nucleosides.
Zidovudine-triphosphate is then included in the terminal fragment of the growing chain of
viral DNA by viral reverse transcriptase, thus causing the viral DNA chain to break apart
in cells infected with the virus.
Zidovudine has been authorized for treating patients with AIDS. It significantly prolongs the life of the patient, although it has a number of toxic effects. Synonyms of this
drug are azidothymidine and retrovir.
Safety
| Symbol(GHS) |    GHS02,GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H303-H225-H301+H311+H331-H370-H351 |
| Precautionary statements | P210-P260-P280-P301+P310-P311-P281-P501a-P201-P202-P308+P313-P405-P501 |
| Hazard Codes | Xn |
| Risk Statements | 40-36/37/38-20/21/22 |
| Safety Statements | 36/37/39-45-36-26 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 3 |
| RTECS | XP2072000 |
| F | 10 |
| Hazard Note | Harmful |
| HS Code | 29349990 |
| Hazardous Substances Data | 30516-87-1(Hazardous Substances Data) |
| Toxicity | LD50 in male, female mice, male, female rats (mg/kg): 3568, 3062, 3084, 3683 orally; >750 i.v. (all species) (Ayers) |
