Stavudine (d4T) , ≥98% , 3056-17-5

Synonym(s):
Stavudine;d4T;1-(2,3-Dideoxy-β-D-glycero-pent-2-enofuranosyl)thymine;1-[(2R,5S)-5-(Hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4-(1H,3H)-dione;2′,3′-Anhydrothymidine

CAS NO.：3056-17-5

Empirical Formula: C10H12N2O4

Molecular Weight: 224.21

MDL number: MFCD00132921

EINECS: 641-374-0

PRODUCT Properties

• Melting point: 159-160°C
• alpha: D25 -39.4° (c = 0.701 in water); D20 -46.1° (c = 0.7 in water)
• Density: 1.374±0.06 g/cm3(Predicted)
• refractive index: -46 ° (C=0.69, H2O)
• storage temp.: -20°C
• solubility: Soluble in water, sparingly soluble in ethanol (96 per cent), slightly soluble in methylene chloride. It shows polymorphism (5.9).
• form: Solid
• pka: 9.47±0.10(Predicted)
• color: White
• Water Solubility: 5-10 g/100 mL at 21 ºC
• BCS Class: 1,3
• Stability: Stable. Combustible. Incompatible with strong oxidizing agents.
• InChIKey: XNKLLVCARDGLGL-JGVFFNPUSA-N

Description and Uses

Stavudine, a dideoxynucleoside analog of thymidine, has been introduced in the U.S.A. for the treatment of late-stage AIDS patients who are refractory to other AIDS treatments. Similar as other currently available agents for AIDS treatment such as zidovudine (AZT), didanosine, and zalcitabine, the anti-HIV activity of these 2'3'- dideoxynucleosides is ascribed to the inhibitory effect of their corresponding 5'- triphosphates against the HlVsncoded RNAdependent DNA polymerase (reverse transcriptase). While some of these drugs have rapid development of drug resistance, stavudine is active against AZT-resistant HIV strains. It has a favorable pharmacokinetic profile with more complete and less variable oral absorption than AZT and didanosine and has a bioavailability of 80-90%.

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Safety

• Symbol(GHS): GHS08
• Signal word: Warning
• Hazard statements: H341
• Precautionary statements: P201-P202-P280-P308+P313-P405-P501
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 2
• RTECS: XP2075000
• HS Code: 29349990
• Toxicity: LD50 oral in rat: 4gm/kg