Home Categories API 3′-Azido-3′-deoxythymidine
A0755312

3′-Azido-3′-deoxythymidine , ≥98%(HPLC) , 30516-87-1

Synonym(s):
3′-Azido-3′-deoxythymidine;Azidothymidine;AZT;ZDV;Zidovudine

CAS NO.:30516-87-1

Empirical Formula: C10H13N5O5

Molecular Weight: 283.24

MDL number: MFCD00006536

EINECS: 623-849-4

Pack Size Price Stock Quantity
1G RMB67.20 In Stock
5G RMB143.20 In Stock
25G RMB484.80 In Stock
100G RMB1480.80 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 113-115 °C (lit.)
Boiling point: 410.43°C (rough estimate)
alpha  D25 +99° (c = 0.5 in water)
Density  1.3382 (rough estimate)
refractive index  47 ° (C=1, H2O)
Flash point: 9℃
storage temp.  2-8°C
solubility  H2O: 50 mg/mL
pka pKa 9.53(H2O t = 25.0±0.1 I = 0.00) (Uncertain)
form  Powder
color  White to Off-white
Water Solubility  1-5 g/100 mL at 17 ºC
Sensitive  Light Sensitive & Hygroscopic
Merck  14,10123
BRN  3595791
BCS Class 1,3
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey HBOMLICNUCNMMY-BWZBUEFSSA-N

Description and Uses

Zidovudine, also known as azidothymidine (AZT), is an antiviral agent acting via reverse transcnptase inhibition. It was first launched in the U.K. and subsequently introduced in over a dozen countries for the management of severe manifestations of HIV infection. In patients with AIDS and ARC, zidovudine reduces the risk of opportunistic infections and prolongs survival time. In symptom-free patients it shows promise in halting further immunological deterioration.

Zidovudine is an antiretroviral drug that is clinically active against HIV-1 and is intended to treat HIV-infected patients. Zidovudine is an analog of thymidine that inhibits replication of the AIDS virus. It also turned into mono-, di-, and triphosphates by the same cellular enzymes that catalyze phosphorylation of thymidine and thymidine nucleosides. Zidovudine-triphosphate is then included in the terminal fragment of the growing chain of viral DNA by viral reverse transcriptase, thus causing the viral DNA chain to break apart in cells infected with the virus.
Zidovudine has been authorized for treating patients with AIDS. It significantly prolongs the life of the patient, although it has a number of toxic effects. Synonyms of this drug are azidothymidine and retrovir.

Safety

Symbol(GHS) 
GHS02,GHS06,GHS08
Signal word  Danger
Hazard statements  H303-H225-H301+H311+H331-H370-H351
Precautionary statements  P210-P260-P280-P301+P310-P311-P281-P501a-P201-P202-P308+P313-P405-P501
Hazard Codes  Xn
Risk Statements  40-36/37/38-20/21/22
Safety Statements  36/37/39-45-36-26
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  3
RTECS  XP2072000
10
Hazard Note  Harmful
HS Code  29349990
Toxicity LD50 in male, female mice, male, female rats (mg/kg): 3568, 3062, 3084, 3683 orally; >750 i.v. (all species) (Ayers)

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